Detecting Miscarriage Triggers: Diagnostic Testing Methods

Majority of people who have one miscarriage go on to have successful pregnancies later.But with two, three or more recurrent miscarriages, the chances are lower and tests are offered to determine the cause.


Symptoms of miscarriage

BLOOD TESTS for Detecting Miscarriage:

1. Lupus anticoagulant antibodies/ Anticardiolipin antibodies:

One of the markers for Antiphospholipid Syndrome, APS (a rare autoimmune disease in which blood clots prevent blood flow).

2. Thrombophilias:

PT (prothrombin time), aPTT (activated partial thromboplastin time), protein C, protein S deficiency, and antithrombin III deficiency can all be linked with recurrent miscarriages.

3. Thyroid Hormones:

Hypothyroidism may increase the risk of second-trimester miscarriage.

4. Progesterone :

Progesterone (a hormone that thickens the lining of the uterus and promotes embryo development) is tested a week after ovulation or on day 21 of a 28-day cycle to check for abnormal levels.

5. Rubella antibody Test:

Woman’s Rubella immunity be tested prior to pregnancy as it possesses a risk to pregnancy, including miscarriage and serious threat to the health of fetus.

6. Other hormones:

Especially in people over 35, test for levels of Follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH), and Luteinizing hormone (LH).

High FSH levels may mean the ovaries lack eggs suitable for pregnancy. Low FSH levels may indicate severe stress, which in turn could contribute to miscarriage.

7. Karyotype Testing:

Performed on both parents to look for problems in the genetic structure (correct number of chromosomes) that might raise pregnancy loss risks, such as balanced translocation.ac

UTERINE TESTS for Detecting Miscarriage:

1. Hysterosalpingogram (HSG):

A dye is injected into the uterus. An X-ray is taken to look at whether the fallopian tubes are open, for abnormal shape of the uterus and for anatomical problems such as fibroids, that can lead to miscarriage.

2. Hysteroscopy:

A thin telescope is inserted into the uterus to view and repair minor problems of the uterus such as  fibroids, large polyps, scar tissue, or a uterine condition that may have been present since birth. 

3. Transvaginal ultrasound:

An ultrasound checks for uterine, ovarian, and endometrial problems that could be contributing to recurrent miscarriages.

4. Endometrial biopsy:

A small piece of the endometrium (the lining of the uterus) is removed to help diagnose infections, fibroids, or polyps, conditions that interfere with conception or pregnancy.

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